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Statistical Mechanics in Systems Biology: Villa Orlandi, Anacapri ~ May 29 - June 1, 2012 |
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Thierry Mora Laboratoire de Physique Statistique, Ecole Normale Superieure, Paris (France) Public good usage in bacterial colonies Siderophores that shuttle between cell periplasms and the environment deliver iron to bacteria. To study the effect of spatial interactions between cells, we measured at the level of single-cell the dynamics of an endogenously fluorescent siderophore in micro-colonies growing on a solid surface. We show that the dynamics is heterogeneous and is correlated over very short range. A microscopic model of exchange between adjacent cells was able to capture the spatio-temporal dynamics of the whole colony. We further show that individual growth rate were correlated to neighbours dynamics. These results emphasise the stabilising role of spatial reciprocity on the maintenance of cooperation. |
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