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Statistical Mechanics in Systems Biology: Villa Orlandi, Anacapri ~ May 29 - June 1, 2012 |
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Daniel Segre' Bioinformatics Program, Department of Biology and Department of Biomedical Engineering, Boston University, Boston, MA (USA) Modeling metabolism at multiple scales Stoichiometric models of metabolic networks for microbial species are increasing in number and improving in accuracy. Yet, some fundamental properties of microbial ecosystems depend on aspects that are beyond the metabolic networks of individual species, such as metabolite-mediated interactions between different microbes and spatio-temporal variation of environmental conditions. Can current models account for such effects, and help understand the dynamics and evolution of microbial communities? We explore possible answers to this question, with applications ranging from synthetic ecology to the organization of the human microbiome. |
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